Apothéke
9 Doyers St, between Pell and Bowery; 212.406.0400
"Location, location, location" means different things to different businesses -- bodegas grab corners to snare foot traffic, while shady accountants occupy 2nd floor offices so passersby'll be reassured their shadiness is legit. Locking down the perfect cranny for a clandestine cocktail bar, Apothéke.
'Theke's barkeeps also take requests, and'll offer a "house remedy" for whatever ails you -- though there is no cure when your location, location, location is always a bar.