When Las Perlas opened in the historic Sante Fe building in downtown Los Angeles in 2010, it was one of the first true mezcal bars in the country. Modeled after traditional Oaxacan cantinas, this mezcaleria features more than 450 different agave spirits and counting. While cocktails are more traditional and mainly riffs on the Margarita or Daisy, you can expect them to come garnished with toppings like wild hibiscus flowers, spicy worm-laden salts, and roasted chapulinas—aka grasshoppers, a delicacy in Oaxaca. Our favorite drink is the Rosemary’s Baby, which is made with mezcal, watermelon agua fresca, honey and blood orange. Most nights, there’s free live music after 10 p.m., which only adds to the bar’s appeal and its deep, Oaxacan vibes.