Parts Unknown: "Charleston"
Season 8, Episode 8
Aside from profiling one of America's (vastly underrated!) food meccas, and doing his usual Bourdain-thing (eating, drinking, culture, etc.), this episode features Tony breaking bread with Bill Murray. Yep, that Bill Murray. This scene alone is worth the price of a Netflix subscription and justifies the existence of the Internet, overall.
Parts Unknown: "Massachusetts"
Season 4, Episode 7
The Massachusetts episode eschews the trappings of Boston, and instead turns its lens on areas like Provincetown -- sentimentally, as this was the spot of Tony's first cooking gig -- and then rural Franklin County to explore New England's devastating heroin epidemic. This episode focuses less on food than most (don't worry -- there's still food and drink aplenty) but remains one of the more memorable episodes due to its heavy (but important) themes and Tony's personal ties to the area.