Ann Arbor, MI
Pickled vegetables are The Brinery's main game, but in the last few years they've entered the hot sauce market with a fermented sauce that's earned them a fierce loyalty that extends to neighboring Detroit.
The official hot sauce of the first Buffalo wing, 'nuff said.
Pain Is Good
Kansas City, KS
Original Juan boasts 15 lines of hot sauce, but their best known is the Pain Is Good line, which ranges from Jamaican to cayenne to fire-roasted green sriracha.