6. Market East
Tucked among City Hall and office buildings, it’s easy to overlook Market East. While most of the notable nightlife spots are located within a two-block radius, those two blocks pack a significant punch. Before the development of Passyunk Ave, 13th St was the go-to street for the best, most innovative restaurants in Philadelphia. Restaurants like El Vez, Zavino, Sampan, or any of the collection in Marcie Turney and Valerie Safran’s mini-empire (Lolita, Barbuzzo, Jamonera, and new-comer Little Nonna's) are all fine choices. After finishing dinner, you’re just a stone's throw away from Graffiti Bar, BRÜ, Opa, and the oldest bar in Philadelphia -- McGillin's.