Since sandwiches are basically the greatest creation since sliced bread (and also include sliced bread... whoa... ), we've gone around the city and rounded up the six most delicious 'wiches you pretty much have to try, because you really haven't lived until you have.
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Roast Turkey Sandwich, Arguello Market
Probably the sandwich on this list most likely to make you say "Huuuuuuh? Na-nah na-nah (na-nah na-nah)", this turkey sando is made from birds roasted on-site with layers of light and dark meat, lettuce, tomato, and pickles... PLUS added pepper jack and avocado. It's like everything a regular turkey sandwich wishes it could be.
Menage a Trois BBQ, Ike's Place
If the line out the door or their app designed specifically for ordering sandwiches didn't already tell you, Ike's has some of the best sandos in the city, and the real champion has to be the perfect combo of three cheeses (cheddar, pepper jack, Swiss), chicken, and three sauces (honey mustard, real honey, and dirty)... which is exactly how you feel after a non-sandwich Menage a Trois.
Pastrami Reuben, Wise Sons
The Mission, SOMA
This reuben with homemade pastrami is the best one you will get outside of New York City. And also in parts of New York City (mostly the Chinatown ones).
Hot Italian Sausage All-in-One, Giordano Bro's
The Mission, North Beach
Sure, this might not be the most high-end sandwich on the list, but if you're watching a game, you really can't go wrong with basically an entire meal in a sandwich. This guy consists of sausage, olive oil & vinegar slaw, Provolone cheese, and French fries. Yeah, that's right, French fries.
Santa Maria Tri-Tip Steak Sandwich, Memphis Minnie's
Aside from the fact that they've probably got the nicest cashier in the city, Memphis Minnie's also demonstrates that sometimes you don't need a lot of extras to make something great, as evidenced by the absolutely delicious tri-tip steak sammy, which you can pair with their South Carolina (mustard-based) BBQ sauce... if you must mess with perfect simplicity.
Pastrami, Darwin Cafe
This semi-hidden SOMA gem (that we keep writing about and unhiding) has a rotating list of sandwiches, so you might not always be able to grab one. But when you get the chance, don't miss out on this pastrami with German potato salad, house-made pickles, Dijon, and Swiss, because this is seriously something worth waiting in their 30-minute line for.
Famous for their slow-roasted turkey, Arguello Market has turned the turkey sandwich into an art form. They'll slice it up fresh for you every day, which'll definitely make shopping for groceries all the more bearable.
Ike's serves up a myriad of delicious sandwiches (with quirky names) and features vegetarian, vegan and gluten-free options to satisfy all. Out of all the sandwich shops in San Francisco, this is the best place for vegetarians and vegans in the area.
If it's a little difficult to make it from your office to the deep Mission-located Wise Sons, you are in luck, because this pastrami paradise has started a delivery service using TCB Courier that -- provided you make a minimum order -- delivers to the less-deep Mission with no extra charge and Downtown for an extra fiver.
Memphis Minnie's is a 1950s' styled BBQ joint that slings eats slow-cooked meats, Southern-style. Minnie's meats pass the taste test by using white oak logs (no gas, no electricity!). This spot has everything from ribs to pulled pork to some killer wings. Meats here can come slathered in savory sauces, so you might need a bib-- we won't judge!
This pint-sized SoMa hideaway doubles as one of San Francisco's best places to camp out with a laptop if you're lucky enough to score some real estate, and also as one of the best damn sandwich shops you'll find anywhere. Get the legendary roast beef, sliced impossibly thin and layered between buttery slices of bread with whatever the fresh veggie du jour may be, and you won't be disappointed.
GB brings its Pittsburgh-style, French fry-stuffed "all-in-one" sandwiches to their Mission space along with a full booze license, 24 beers on tap, house-constructed pierogies, and seven flatscreens, which they promise won't (Mendenh)all be playing the Steelers.