By this point, though, we've gotten some more plot-heavy trailers that make everything a bit more clear. All of that vague language about connections became more concrete with a new trailer, titled "Briefing," that was released during the Tokyo Game Show in September. Amelie (Lindsay Wagner), presumably the next leader of the United States, brings Sam in to conference with both her and Die-Hardman. Amelie is taking over for her now-deceased mother, who died unable to fulfill her goal of reconnecting the country as the United Cities of America (UCA).
We learn that Amelie put together an expedition with a group of Bridges agents and traveled West, managing to evade and protect her forces from BTs along the way while recruiting communities to join the UCA. They made it all the way to to Edge Knot City, a Pacific Coast stronghold controlled by the Homo Demons, who capture Amelie, intending to use her as leverage to maintain Edge Knot City's independence from the UCA.
Now, Amelie and Die-Hardman want to recruit Sam to continue Amelie's work, bringing disconnected Chiral networks online across the nation and eventually rescuing Amelie so that she can reassume the presidency. In the trailer, Sam is too skeptical and jaded to accept and storms out of the room. However, he's is later seen in trailers with the key ring-like device (called a "Cupid") that Die-Hardman tries to pass on in the trailer. Therefore, it's pretty safe to assume that at some point, he does agree to take on Amelie's mission and sets off on a cross-country journey.