The Shepard Fairey OBEY logo (circa '89), the Lord of the Rings-inspired "Frodo Lives" graffiti (circa 1970), and the Church of the SubGenius (circa '59) are all prime examples; other transferable doodles like "Kilroy was here" and the "stussy S" spread through textbooks, walls, and basically every other surface you could mark as a counterculture statement and a precious in-joke.
"All those joke archetypes could definitely be considered memes," Jenkins said. "There's just so much there. I think I should tell you, finding the first meme is just an incredibly complicated task." Yes, thanks for the heads up.
But there are two ancient instances in particular that fit my M.E.M.E. construct like a Nintendo Power Glove. The messages have had influence on a global scale, are universally relatable, have been infinitely adapted, and even have modern (super-annoying) analogues. Spoiler: They're about death and dicks.