What's it about... other than sex?
This all stems from the show's clever hook: Otis (Asa Butterfield) is the shy son of the gregarious, bawdy sex therapist Jean (Gillian Anderson). This causes a host of emotional issues for him, but it puts him in a unique position in his secondary school, Moordale. When a bully with performance issues and a, uh, large member gets an overzealous erection thanks to some Viagra, Otis gives him some quick therapy from inside an abandoned bathroom -- and it works. Effortlessly cool feminist Maeve (Emma Mackey) hears this play out and spots a business opportunity: Otis will counsel his fellow teens on their sexual problems, Maeve will court the clients, and they'll split the earnings. (This is not unlike the underrated Anton Yelchin teen flick Charlie Bartlett, except Otis isn't writing any prescriptions here.)
Of course, nothing is that simple, and while the nervous Otis does have a strange gift for getting to the root of other people's problems, he can't even begin to deal with his own, which include an inability to masturbate, a crippling crush on Maeve, and a distance from his best friend Eric (Ncuti Gatwa). Meanwhile, Maeve, clearly the smartest person in school, is struggling to find her footing after being abandoned by her drug addict mother and her unreliable brother. A relationship with swim team star Jackson (Kedar Williams-Stirling) offers some stability, but he is also buckling under the pressure of being an athlete to watch. And then, to round out Otis and Maeve's trio, there's the boldly fashionable Eric, a gay man who has come out at school, but begins to feel more and more isolated as Otis becomes preoccupied with his burgeoning business.