If a coworker is aggravating you, close your door or put on headphones. If they're really aggravating you, tell them to fuck off (professionally and politely, definitely don't say "fuck off"). Turn off your phone after leaving the office, even if it's just for an hour. After some initial anxiety, you'll start to feel better about not being tethered to work all the time.
Use idle time to learn new skills
If you have a job with lots of downtime, use it to plan your next career move or learn new skills, like Photoshop or coding. Likewise, budding writers can keep Word open on their computer and chip away at the next great American novel sentence by sentence. It’s easy to minimize those windows on your computer and pretend you’re doing actual work.