You'll probably have to take a trial-and-error approach
While the general pillars of weight loss hold true -- eat healthy, exercise often, get enough sleep -- in what amounts, and what "eat healthy" means specifically, can vary from person to person. Unfortunately, treatment is usually relegated to a trial-and-error process, until people can find out exactly what will work for them in terms of weight loss.
Dr. Kaplan, for example, told The New York Times he has 40 different therapies he tries with obese patients, including different diets, aerobic exercise, sleep enhancements, and more than a dozen drugs.
And even if someone initially loses weight, being able to keep it off is key. Most people who lose weight will gain it back, making a comprehensive treatment for obesity that much more difficult.