"Jet lag" isn’t the only problem that palmitate causes for cells. It also induces inflammation in several different cell types. These two effects fluctuate in sync. For instance, in fat cells, both the inflammatory and jet-lagging effects appear to peak at night. While there is no good time to eat saturated fat, it's probably not a great idea to eat a meal rich in these "bad" fats late at night.
We also tried to find out whether specific polyunsaturated "good" fats had protective effects on cells, and could counteract palmitate's jet-lagging and inflammatory effects.
We found that DHA, a common omega-3 polyunsaturated fatty acid, is anti-inflammatory. Besides inhibiting the inflammatory response to palmitate, this omega-3 also prevented cell clocks from being reset.