Depending on how the weather holds up, it should be fairly simple to spot the meteors, seeing as they'll appear to originate in the vicinity of the constellation Orion, hence the shower's name. Just look for the three bright stars that make up Orion's Belt (Hint: not around a cat's neck). However, the meteors will only appear for about a second, so you'll have to keep your eyes glued to the sky in between sips of coffee.
As you might expect, the weather can make or break the quality of the show. Observers in the Southeastern US will have some of the best viewing conditions, according to AccuWeather Meteorologist Steve Travis. But folks in the Great Lakes region and New England likely won't be as lucky, thanks to a weather system and clouds that will spread across the regions, respectively, per the AccuWeather report. Thankfully, you can always watch a live broadcast of the meteor shower on Slooh starting on Wednesday at 8pm ET.