Despite only being around for a few weeks, Pokémon Go has grabbed the world by the Pokéballs and won't let go until you've caught 'em all. But with that in mind, you should ensure you're making the most of your Pokétime while pursuing all 142 available monsters.
To do that, there's a good chance you're going to invest in Pokécoins, since they're kinda hard to come by. No sweat.
If you've managed to earn enough PokéCoins to splurge, or you've finally decided to spend real dollars to upgrade your gear, there's one thing you DEFINITELY need to spend on above all others: Bag Upgrade.
While all the items for sale in the Shop conceivably help, two items aren't available through PokéStops or leveling up: the Bag Upgrade and Pokémon Storage Upgrade. The difference here, though, is that you don't really need the Pokémon Storage Upgrade unless you're into having tons of garbage Pokémon on your person. Who can ever get enough Pidgey?
You'll always have an incubator, you'll get PokéBalls all the time, and you'll occasionally stumbled on Lucky Eggs, Lure Modules, and Incense. But Bag Upgrade and Storage Upgrade, not so much.