Of course, the odds of winning both jackpots are astronomically slim. Individually, the odds of winning the Mega Millions is 1 in 258,890,850, while the odds of hitting Powerball are 1 in 292,201,338. You have a better chance of being killed by a vending machine or being sainted by the Pope than winning either. The odds jump to a mind-boggling 1 in 75,648,252,765,957,300 (yes, that's quadrillion) for winning both. But hey, it could happen!