Get a flu shot
This is basically the definition of an easy, common-sense way to avoid getting sick -- and not just on airplanes. If you're old enough to read this, you're among the group of people the Centers for Disease Control & Prevention recommends getting a flu shot every year. Oh, and a lot of places give them away from free, so we're not going to call you an idiot if you don't get one, but...
Be in good health when you get on the plane
Turns out that of your best defenses against catching a cold when flying is maintaining a healthy lifestyle before you even set foot in the airport, according to the report. This means getting enough sleep, plenty of exercise, and eating nutritious foods. Experts say all of these things can collectively help your body fight infections.
Again, these are simple -- if not obvious -- steps you can take to prevent a cold from ruining your Thanksgiving. The thought of being too congested to properly taste all that turkey, stuffing, and pumpkin pie should be enough to motivate you. Although, your grandma will probably still want a kiss, even if you're sick.