Everyone knows that feeling. You have some excellent spicy food. It's delicious going in. It's torturous coming out. Well, as SciShow explains in a new video, that's in part because there are more similarities between your mouth and your butthole than you'd probably care to admit.
When you eat something spicy, the spiciness of that food often comes from the compound capsaicin. As SciShow explains above, capsaicin binds to your TRPV1 receptors. One of the jobs of these receptors is to detect heat, which is why you feel the delicious burning in your mouth when you eat foods containing the compound.
However, TRPV1 receptors are all over your body, because any body part might bump the hot stove. Like with any amount of heat the body detects, your body attempts to cool down when you eat spicy food. That's why you have reactions like sweating that are more frequently triggered by a hot summer day or bustling kitchen.
As you might have guessed at this point, there are TRPV1 receptors in your anus.