Art truly is the ultimate conversation starter, even if all of those conversations start with "I see you too enjoy the works of Thomas Kinkade". For wall hangings that'll start conversations you actually want to be a part of, check out 8 Bit Wood.
The pet project of a big-time LA video game developer, Wood pays homage to NES awesomeness, by cutting/ staining/ glueing/ sealing thousands of little blocks o' wood to create wall-ready pixel pieces that portray all-time great gaming icons, from Mario to Link, who proved so influential they even named 'net URLs after him. Epically cool good-guy installations include an almost 3' Contra dude, which comes with an accompanying (and totally devastating) Spread Power-up icon; a double-sided wall-climbing, extra-sneaky Ryu from Ninja Gaiden; and a mid-jump Mega Man package that also includes three Mega bullets and an unsuspecting Cut Man, aka Trent Edwards. Non-heroic, but still cool subject matter includes a Duck Hunt joint with that jerk laughing dog and two totally un-shootable-unless-you-pressed-the-gun-to-the-screen birds, and the only non-NES hanging: a tribute to Adventure for Atari 2600, for which your great-aunt is still somehow buying you games.
For Punch-Out fans, there's also a "life-size" Glass Joe in the works that'll be over 6' (2,500 total pixels) and capture him mid-uppercut to the jaw -- yet another conversation starter, even if all those convos start with "you have the right to remain silent".