First, go to System Preferences (either via the Apple icon on the navigation bar along the top of the screen or the cog wheel in the application dock). Find the "App Store" icon and click it.
Now, uncheck the box that says "Automatically check for updates." This does exactly what it sounds like: liberates you from the barrage of pop-up notifications we all hate. Freedom! (By the way, if you're also being plagued with constant "Not Enough Storage" alerts on your iPhone, there's a fix for that, too.)
Here's the caveat: ditching regular software update install reminders is one thing, but not updating your Mac software is bad. So, if you're going to forego the reminders altogether, you'll want to periodically check in and see what needs an update every month or two. This is easy -- simply go back to the App Store and it'll show you a comprehensive rundown of every available update, and give you the option to download them right then and there.
Sign up here for our daily Thrillist email, and get your fix of the best in food/drink/fun.