4. Napa Valley, CA
Must-hit wineries: Honig Winery, Opus One
"Napa is like the Vegas of wine," says Grandison. "Everyone knows about it, you'll drop a ton of cash, you'll have to deal with the crowds, but you also fly home thinking to yourself: 'Yeah, that was a great time.'" The big names in American wine are all in Napa -- Joseph Phelps, Duckhorn, Mondavi, Opus One -- and that’s probably why it produces about 4% of all the juice nationwide. But the big names in food are here too -- from the French Laundry to La Toque -- and if you're willing to spend the cash, it's tough to beat. Plus, it's home to the limousine wine tour, so you'll be sharing your tasting room with at minimum two bachelorette parties!