Getting to Guyana, and where to stay
Direct flights link Georgetown with New York (JFK), Miami, London, and nearby Trinidad. Short internal flights on small bush planes are helpful in reaching ecolodges and the deep rainforest. Backpackers can enter overland from Brazil at Lethem and for a slower adventure, you can take the bus all the way to Georgetown.
My personal recommendation is to book at least a few nights at the tribal-owned ecolodges of Guyana’s wild interior -- or, to get the full experience, plan a series of ecolodge visits over the course of a week. Where else do you get to stay as a guest of the tribe, explore nature with the people who know it best, and contribute directly to a sustainable conservation project? Rewa Lodge is my favorite, but also check out Karanambu Ranch and Surama.
Get your shots, and beware of bug bites
Guyana is a tropical destination, which means serious insects for part of the year and the ever-present reality of malaria and dengue. Consult your doctor beforehand for malaria prophylaxis, but most travelers take the basic precaution of applying mosquito repellent and sleeping under mosquito nets (which are included at most hotels and lodges). As with most of South America, yellow fever vaccination is recommended.