Ticket price: $383
Built onto the foothills of soaring mountains and active volcanoes, Quito is one of the most beautiful and vibrant South American capitals. It’s also the home base for a wide world of adventure tourism. High in the Andes, Quito is a mix of modern and indigenous, with luxury high rises, local markets, shamans, artisans, and an Old Town that was named a UNESCO World Heritage Site. And backpackers delight in the Mariscal neighborhood, which is teeming with wayfaring gringos who camp out at the karaoke bars and hostels.
What to do: Head just outside the city to Cotopaxi National Park, where you can rent mountain bikes and ride down the face of this still-active volcano.