The City by the Bay boasts about as many neighborhoods as hotels. Luckily for you, we've taken it upon ourselves to round up the cream of the crop, whether you want to vacation like a rockstar, or just think you're Turning Japanese. Here are our picks

Hotel Adagio 550 Geary Street; Downtown; 415.775.5000 Proudly mounted in the Theatre District amidst the burgeoning heart of downtown, Adagio hides its contempo-upscale aesthetic (spread out across 171 rooms and a hip lounge dubbed Mortimer Bar) inside a Spanish colonial revival building originally erected in 1929. Read the full review...
Grand Hyatt San Francisco 345 Stockton Street; Union Square; 415.398.1234 The jack of all trades of SF lodging, the Grand Hyatt's a 660-room mega-hotel catering to both the business & recreational set with its cocktail lounge, American bistro, and shloads of amenities. Read the full review...
Mystic Hotel 417 Stockton Street; Union Square; 415.400.0500 You'd think a hotel owned by renowned chef Charlie Palmer would serve superlative cuisine... and you'd be right! Witness Mystic Hotel, a modernized, Union Square-adjacent home away from home offering dapper accommodations, top-notch vittles, and one of the San Fran's hottest speakeasies. Read the full review...
The Fairmont 950 Mason Street; Nob Hill; 415.772.5000 Located at the most important locus in SF (where all of the cable car lines meet!), Fairmont offers almost-too-easy access to Downtown, FiDi, Union Square, and Fisherman's Wharf, not to mention unobstructed panoramic views of the city, and a restaurant with a freaking pool in the middle of it. Read the full review...
Serrano Hotel 405 Taylor Street; Downtown; 415.885.2500 Just like the famed pepper found in the mountainous regions of the Mexican states of Puebla and Hidalgo, Serrano's a spicy-hot, four-star boutique hotel located just blocks away from Union Square that features in-room spa services and a Yoga channel on every TV, making the painstaking task of finding your chi easier than ever. Read the full review...
Sir Francis Drake Hotel 450 Powell Street; Union Square; 415.392.7755 Not the 16th-century sea captain & navigator, but certainly worthy of housing him, Sir Francis Drake is a Union Square hotel decidedly dripping with class and sophistication. With food plated by Top Cheftestants Jennifer Biesty & Tim Nugent and the speakeasy known as Bar Drake, you'll have plenty of exploring to do yourself. Read the full review...
Phoenix Hotel 601 Eddy Street; Tenderloin; 415.413.0900 Planted on the edge of the Tenderloin, Phoenix Hotel prides itself on its atmosphere, knowledgeable staff, and rockin' guest list that has included such talent as The Shins, Little Richard, and Pearl Jam. Read the full review...
Hotel Kabuki 1625 Post Street; Japantown; 415.922.3200 Established in the heart of Japantown, Kabuki brings together Eastern and Western influences to create a relaxing environment that North and South just wouldn't understand. Read the full review...

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1. Hotel Adagio 550 Geary St, San Francisco, CA 94102 (Downtown)

Proudly mounted in the Theatre District amidst the burgeoning heart of downtown, Adagio hides its contempo-upscale aesthetic (spread out across 171 rooms and a hip lounge dubbed Mortimer Bar) inside a Spanish colonial revival building originally erected in 1929.

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2. Grand Hyatt San Francisco 345 Stockton Street, San Francisco, CA 94108 (Union Square)

The jack of all trades of SF lodging, the Grand Hyatt's a 660-room mega-hotel catering to both the business & recreational set with its cocktail lounge, American bistro, and shloads of amenities.

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3. Mystic Hotel 417 Stockton St, San Francisco, CA 94108 (Union Square)

Witness Mystic Hotel, a modernized, Union Square-adjacent home away from home offering dapper accommodations, Charlie Trotter vittles, and one of the San Fran's hottest speakeasies.

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4. The Fairmont 950 Mason St, San Francisco, CA 94108 (Nob Hill)

The Fairmont Hotel has three dining options: the seafood-focused Laurel Court Restaurant & Bar, Caffe Centro, and the famous Tonga Room & Hurricane Bar, which has been a tiki-bar must-see for locals and tourists since 1945. Enjoy a strong, fruity cocktail among tropical decor as you watch a live band perform -- on a boat, in the middle of the restaurant, while it “rains” inside.

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5. Serrano Hotel 405 Taylor St, San Francisco, CA 94102 (Downtown)

Serrano's a four-star boutique hotel located just blocks from Union Square that features in-room spa services, a fitness center, and a Yoga channel on every TV. They're equipped to give you local tips on the nest undiscovered spots to investigate and make your own. Did we mention it's pet friendly? Also, Nintendos!

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6. Sir Francis Drake Hotel 450 Powell St, San Francisco, CA 94102 (Union Square)

Refurbished in 2011, Sir Francis Drake Hotel was built in 1928 and is a half-block from San Francisco's Union Square. The hotel's renaissance-influenced architectural splendor is sophistication with a touch of regal. (Maybe that's why all the doorstaff are dressed in full Beefeater regalia?)

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7. The Phoenix Hotel 601 Eddy St, San Francisco, CA 94109 (The Tenderloin)

Planted on the edge of the Tenderloin, Phoenix Hotel prides itself on its atmosphere, knowledgeable staff, and rockin' guest list that has included such talent as The Shins, Little Richard, and Pearl Jam. Voted #1 Hippest Hotel by Travel and Leisure magazine in 2012, The Phoenix is for the traveller who wants to be in the thick of things as opposed to getting away from it all.

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8. Hotel Kabuki 1625 Post St, San Francisco, CA 94115 (Japantown)

Established in the heart of Japantown, Kabuki brings together Eastern and Western influences to create a relaxing environment that North and South just wouldn't understand. Find your zen balance in the tranquility of their accommodations.

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