Domilise's Po-Boys, New Orleans
Martine Boyer/Thrillist

Domilise's Po-Boys

New Orleans
$$$$
Domilise's Po-Boys

5240 Annunciation St

New Orleans, LA 70115

Under the same family ownership for over 100 years, Domilise's is something of a New Orleans po-boy haven. Inside a boxy pale-yellow building and distinguished only by a hand-painted sign, Domilise's would be easy to miss if it weren't for the line that typically stretches out the door. The catfish and fried oyster po-boys are among the most popular items on the menu, but guests have the option to split their sandwiches half-and-half with other toppers like shrimp and roast beef. Half-shrimp and half-oyster on the same bun is the move, if you ask us.