Venue Info

Under the same family ownership for over 100 years, Domilise's is something of a local New Orleans po-boy haven. While the legendary spot is unassuming, tucked inside a little yellow house on an Uptown corner, distinguished only by a hand-painted sign, it is relatively hard to miss due to the line that typically stretches out the door. Widely recognized for consistently good eats and veritable Southern hospitality, Domilise's has no trouble maintaining a steady crowd of regulars. The catfish and fried-oyster po-boys are among the most popular menu items, but guests can top their sandwiches with everything from pork sausage and roast beef, to shrimp and turkey breast. The Louisiana mainstay is something of a landmark for po-boy connoisseurs, and eat-seeking tourists, alike.

Domilise's Po-Boys, New Orleans

Domilise's Po-Boys

Martine Boyer/Thrillist

Under the same family ownership for over 100 years, Domilise's is something of a local New Orleans po-boy haven. While the legendary spot is unassuming, tucked inside a little yellow house on an Uptown corner, distinguished only by a hand-painted sign, it is relatively hard to miss due to the line that typically stretches out the door. Widely recognized for consistently good eats and veritable Southern hospitality, Domilise's has no trouble maintaining a steady crowd of regulars. The catfish and fried-oyster po-boys are among the most popular menu items, but guests can top their sandwiches with everything from pork sausage and roast beef, to shrimp and turkey breast. The Louisiana mainstay is something of a landmark for po-boy connoisseurs, and eat-seeking tourists, alike.