Noble Experiment calls itself a speakeasy, but it's not much of a secret. The popular drinking den inside Gaslamp Quarter's Neighborhood is so popular that you won't be able to get in without reserving a spot a few days in advance. Trust us though, it's worth it. What looks like a stack of kegs by the restaurant's bathroom is a door that'll lead you to a bar that's best described as vampire's lair meets French catacombs. Order from a simple menu of handcrafted cocktails or take a chance with the Dealer's Choice -- a bartender will concoct something for you based on your personal tastes, and they almost always nail it. Don't let the wall of gilded skulls freak you out, it's all part of the charm.