61 E Madison St
Chicago, IL 60603
This Chicago mini chain comes from a line of pizza royalty -- as the story goes, Rudy Malnati Sr. is one of the people credited for inventing deep dish at Pizzeria Uno, and his son Rudy launched Pizano's while his other son Lou founded Lou Malnati's. Pizano's uses a recipe similar to that of the original Uno -- the pies are made with a biscuit-like shortbread dough and topped with cheese then chopped tomatoes. If a thousand calorie slice of deep-dish isn't what you're in the market for, you'll find just as satisfying a meal in Pizano's thin-crust pies and pasta specials.